Schmerz ache aches and pains afflict agitate angst anguish anxiety bitterness bleakness boredom bother burden care cheerlessness comfortlessness depression difficulty discomposure discontent dislike dismalness dismay displeasure disquiet dissatisfaction distress distressfulness disturb dolor dread dreariness dullness emptiness ennui existential woe flatness grief grieve grievousness grimness hardship hurt hurting inconvenience inquietude irritation joylessness lack of pleasure lament lamentability lamentation load with care malaise misery mourn mournfulness nausea nongratification nonsatisfaction nuisance pain painfulness pathos perturb pitiability pitiableness pitifulness poignancy put to it regrettableness sadness savorlessness sharpness soreness sorrow sorrowfulness spleen staleness suffering tastelessness tediousness tedium trouble twinge uncomfortableness unease uneasiness unhappiness unpleasure unsatisfaction upset vexation vexation of spirit woebegoneness woefulness worry